{ "@context": "http://iiif.io/api/presentation/3/context.json", "id": "https://digital.middlesexcollege.edu/iiif/manifest/AA00002891/00001", "type": "Manifest", "label": { "none": [ "Big Data Analysis on Adverse Effects of Aquatic Pharmaceutical Contaminants to Human Health" ] }, "metadata": [ { "label": { "en": [ "Abstract" ] }, "value": { "none": [ "A recent publication by the USGS reported the presence of 88 pharmaceutical compounds in 308\nstreams across the USA. These findings point to a nation-wide environmental concern and pose\na risk to human and aquatic-ecosystem\u2019s health. Hence there is a need to generate a complete\npicture of disease risk, by constructing a conceptual map illustrating the link between the\ncontaminating chemicals and diseases. This study is not simple, given the complex nature of\ndisease mechanism and the mode of action of the chemicals analyzed. Today where analytical\nchemistry methods are useful in detecting the presence of pharmaceuticals in water, they are\ninsufficient to understand the direct, harmful effects of pharmaceuticals getting into humans\nthrough the ecosystem of the water bodies. Herein, we have carried out \u201CBig Data\u201D analysis to\nidentify the disease-association of these 88 compounds. We have extracted data from the\nComparative Toxicogenomics Database, Drugbank and used the Cytoscape software to construct\nthe chemical-disease networks to explore the breadth of the issue. Using Cytoscape to study\nbiological networks, begins with building a combined network for the topic of interest and\nmapping the curated network for analysis. Being able to visualize combined and curated data\nallows the researcher to understand and evaluate targeted information. In our studies the (a) 88\nchemicals were linked to about 2208 data points spanning several diseases; (b) diseases were\ndistributed in 19 classes; (c) Disease/Chemical associations were generated for the most harmful\nchemicals and major diseases. Hence, the disease map generated by this study can be helpful in\nstrategizing proper healthcare efforts in the event of a contamination crisis." ] } }, { "label": { "en": [ "Publication Date" ] }, "value": { "none": [ "2021" ] } }, { "label": { "en": [ "Hierarchical Spatial" ] }, "value": { "none": [ "New Jersey -- Edison" ] } }, { "label": { "en": [ "Holding Location" ] }, "value": { "none": [ "Middlesex County College Institution" ] } }, { "label": { "en": [ "Permanent Link" ] }, "value": { "none": [ "http://middlesexcc.sobeklibrary.com/AA00002891/00001" ] } }, { "label": { "en": [ "Creator" ] }, "value": { "none": [ "Trivedi, Nirali", "Ganesan, Vinayak", "Ghosh, Phalguni" ] } }, { "label": { "en": [ "Publisher" ] }, "value": { "none": [ "Middlesex College" ] } }, { "label": { "en": [ "Place of Publication" ] }, "value": { "none": [ "Edison, NJ" ] } }, { "label": { "en": [ "Type" ] }, "value": { "none": [ "Mixed Material" ] } }, { "label": { "en": [ "Source Institution" ] }, "value": { "none": [ "Middlesex County College Institution" ] } }, { "label": { "en": [ "Subjects / Keywords" ] }, "value": { "none": [ "College students -- poster presentations", "Student Works -- Natural Sciences -- poster presentations", "Molecular Biology", "Biochemistry", "Middlesex College (Edison, NJ) -- Student works", "Middlesex County College (Edison, NJ)", "big data analysis; ", "chemical-disease networks", "pharmaceutical contaminants", " network biology", "Human Health", "environment" ] } }, { "label": { "en": [ "Temporal Coverage" ] }, "value": { "none": [ "Academic Year 2020-2021 ( 2020 - 2021 )" ] } }, { "label": { "en": [ "Title" ] }, "value": { "none": [ "Big Data Analysis on Adverse Effects of Aquatic Pharmaceutical Contaminants to Human Health" ] } }, { "label": { "en": [ "Series Title" ] }, "value": { "none": [ "Student Symposium 2022" ] } }, { "label": { "en": [ "Format" ] }, "value": { "none": [ "Mixed Material" ] } }, { "label": { "en": [ "Digital Resource Creation Date" ] }, "value": { "none": [ "1/12/2023" ] } } ], "service": [ { "@context": "http://iiif.io/api/search/2/context.json", "id": "https://digital.middlesexcollege.edu/iiif/manifest/AA00002891/00001/search", "type": "SearchService2", "profile": "http://iiif.io/api/search/2/search" } ], "seeAlso": [ { "id": "https://digital.middlesexcc.edu/content/AA/00/00/28/91/00001/AA00002891_00001.mets.xml", "type": "Dataset", "format": "application/mets\u002Bxml", "label": { "en": "METS" } }, { "id": "https://digital.middlesexcc.edu/content/AA/00/00/28/91/00001/marc.xml", "type": "Dataset", "format": "application/marcxml\u002Bxml", "label": { "en": "MARCXML" } } ], "items": [] }