Cheminformatics and Bioinformatics of Diverse Roles of Fe (II) & Fe (III) in Biomolecules

Material Information

Title:
Cheminformatics and Bioinformatics of Diverse Roles of Fe (II) & Fe (III) in Biomolecules
Abbreviated Title:
Student Symposium 2020
Creator:
Gomez, Mauricio, Jr. ( Author, Primary )
Middlesex College Department of Natural Sciences ( Sponsor )
Ghosh, Phalguni ( Thesis advisor )
Place of Publication:
Edison, NJ
Publisher:
Middlesex College
Publication Date:

Subjects

Subjects / Keywords:
College students -- poster presentations ( lcsh )
Student Works -- Natural Sciences -- poster presentations ( lcsh )
Chemistry ( lcsh )
Biochemistry ( lcsh )
Middlesex College (Edison, NJ) -- Student works
Middlesex County College (Edison, NJ) ( lcsh )
Temporal Coverage:
Academic Year 2020-2021 ( 2020 - 2021 )
Spatial Coverage:
New Jersey -- Edison

Notes

Summary:
Metals play diverse roles in the biological system. Several transitional metals have been reported to play important roles in the biological process; however, the enzymatic activities performed by Fe (II) and Fe (III) metal centers with octahedron geometry are presented in this research. The metal Fe in proteins was found perform the following enzymatic activities; oxidoreductase, transferase, hydrolase, lyase, and isomerase. Moreover, in the enzyme class of ligase, Fe (II) or Fe (III) was not in in proteins performing ligase activities. To conduct this study, the aid of web databases was predominant. Brenda, MetalPDB, RCSB, Uniprot, and PubMed were explored to find particularly important information about the biochemicals roles of the Metallo proteins encompassing Fe as the active Metal centers. It was found that in the oxidoreductase activities only Fe (II) in octahedral geometry is only used to perform this enzymatic activity. For transferase hydrolase activities, Fe (II) and (III) with whether histidine or heme ligand is used to perform the same transferase activity. For hydrolase activities, both Fe (II) & (III) are used to perform hydrolase activities. For Lyase, when a protein uses Fe (III) as an active center it uses neither histidine nor heme. For isomerase, only one protein was found having Fe (II) as the metal center. For the ligase activities, there were no proteins utilizing octahedral Fe centers to perform this activity.

Record Information

Source Institution:
Middlesex County College Institution
Holding Location:
Middlesex County College Institution
Rights Management:
All applicable rights reserved by the source institution and holding location.

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