Synthesis of Amino-Aldehydes from Activated Amino Acids

Material Information

Title:
Synthesis of Amino-Aldehydes from Activated Amino Acids
Series Title:
Student Symposium 2016
Creator:
Pho, Than ( Author, Primary )
Middlesex College Department of Natural Sciences ( Sponsor )
Ghosh, Phalguni ( Advisor )
Lavey, Brian ( Advisor )
Place of Publication:
Edison, NJ
Publisher:
Middlesex College
Publication Date:

Subjects

Subjects / Keywords:
College students -- poster presentations ( lcsh )
Student Works -- Natural Sciences -- poster presentations ( lcsh )
Chemistry ( lcsh )
Biochemistry ( lcsh )
Middlesex College (Edison, NJ) -- Student works
Middlesex County College (Edison, NJ) ( lcsh )
Student Works -- Natural Sciences -- academic theses
Temporal Coverage:
Academic Year 2016-2017 ( 2016 - 2017 )
Spatial Coverage:
New Jersey -- Edison

Notes

Abstract:
A method for the synthesis of Amino-Aldehydes starting from natural amino acids is reported. Glycine and Di-tert-butyl dicarbonate (Boc2O)were prepared through the reaction of protected amino aldehydes obtained from starting material.In the first part of this project, we explored the direct reagent reaction between Glycine and Boc is 1-Ethyl-3-(3-dimethylaminopropyl) carbodiimide (EDC). The reaction was set under normal condition and room temperature. When reacting with NaBH(OAc)3, we got the final product.Detail characterization of a product was determinedby TLC and NMR. In the second part of this project, we explored the stronger reagent reaction byusing Pivaloyl Chlorideinstead of EDC. We got an unknown compound, and we could not identify the structure of this compound until we took NMR. In the third part of this project, we explored thestrongest reagent reaction by using TosylChloride instead of EDC and Pivaloyl Chloride.We got the unknown compound products, then took an unknown product to react with methanol andNaBH(OAc)3 to get the final product. We got an unknown compound, and we could not identify the structure of this compound until we took NMR

Record Information

Source Institution:
Middlesex County College Institution
Holding Location:
Middlesex County College Institution
Rights Management:
All applicable rights reserved by the source institution and holding location.

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