Designing molecules to inhibit Mycobacterium Tuberculosis

Material Information

Title:
Designing molecules to inhibit Mycobacterium Tuberculosis
Series Title:
Student Symposium 2017
Creator:
Lim, Eujin ( Author, Primary )
Ghosh, Phalguni ( Advisor )
Rowley, Steven ( Advisor )
Lavey, Brian ( Advisor )
Place of Publication:
Edison, NJ
Publisher:
Middlesex College
Publication Date:

Subjects

Subjects / Keywords:
College students -- poster presentations ( lcsh )
Student Works -- Natural Sciences -- poster presentations ( lcsh )
Molecular Biology ( lcsh )
Biochemistry ( lcsh )
Middlesex College (Edison, NJ) -- Student works
Middlesex County College (Edison, NJ) ( lcsh )
Temporal Coverage:
Academic Year 2017-2018 ( 2017 - 2018 )
Spatial Coverage:
New Jersey -- Edison

Notes

Abstract:
Tuberculosis is the ninth deadliest disease in the world, killing 1.4 million people yearly. The mycolic acid coating the outside of the bacteria is what makes the tuberculosis difficult to treat. With the addition of mutations in the genes of the bacteria, traditional first line drugs, such as Rifampicin and Isoniazid, are rendered useless. The goal of my research was to build a new inhibitor for the Mtbenzyme, Fatty acid degradation D32, better known as FadD32. This enzyme contributes to the condensationof mycolic acid. The purpose of this research is to not only develop a new inhibitor for this enzyme, but to designnew molecules that have never been tested to our knowledge before. If this research is successful, then the inhibitor could potentially be further synthesized into a drug to treat patients with MTB.

Record Information

Source Institution:
Middlesex County College Institution
Holding Location:
Middlesex County College Institution
Rights Management:
All applicable rights reserved by the source institution and holding location.

MCC Membership

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Middlesex College
Student Symposium
Student Works