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Amine-Catalyzed Direct Asymmetric Mannich Reaction
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001
AA00002430_00001
005
20210622145308.0
006
m^^^^^o^^^^^^^^^^^
007
cr^^n^---ma^mp
008
210622n^^^^^^^^xx^^^^^^s^^^^^^^^^^^eng^d
245
00
|a
Amine-Catalyzed Direct Asymmetric Mannich Reaction
|h
[electronic resource].
260
|a
Edison, NJ :
|b
Middlesex College,
|c
2015 December 23.
490
|a
Student Symposium 2015.
520
3
|a
We explored the natural amino acid L-proline to be catalysts for the direct asymmetric Mannich-type reaction of acetone with a variety of preformed aldimines derived from o-anisidine. In the first part of this project, we explored the direct asymmetric Mannich-type reaction between acetone and N-(p-nitrobenzylidene)Aniline, in the presence of 30 mol % of L-proline.N-(p-nitrobenzylidene)Aniline was the intermediate compound which made between Aniline and 4-nitrobenzaldehyde.The reaction was set under normal condition and room temperature. We got 2 conformation products. Detail characterization of two products was determined by TLC, Column Chromatography, NMR, and HPLC. The percent yield of main product was 67.5%, and the published value was 52%. In the second part of this project, we explored the same asymmetric Mannich-type reaction using p-Anisaldehyde instead of 4-nitrobenzaldehyde. We got an unknown compound, and we could not identify the structure of this compound until we get mass spectrum. In the third part of this project, we explored one-pot three-component reaction between acetone, Aniline, and p-Anisaldehyde in the presence of 30 mol % of L-proline. We got 2 conformation products too, but the ratio of major and minor conformers is switched.
533
|a
Electronic reproduction.
|c
Middlesex County College Institution,
|d
2021.
|f
(Middlesex County College)
|n
Mode of access: World Wide Web.
|n
System requirements: Internet connectivity; Web browser software.
535
1
|a
Middlesex County College Institution.
648
|a
2015-2016
|y
Academic Year 2015-2016.
650
0
|a
College students -- poster presentations.
650
0
|a
Student Works -- Natural Sciences -- poster presentations.
650
0
|a
Chemistry.
650
0
|a
Student works -- Natural Sciences -- academic theses.
650
|a
Middlesex College (Edison, NJ) -- Student works.
650
0
|a
Middlesex County College (Edison, NJ).
700
1
|a
Zhang, Xiaoqiao (Kerry Zhang),
|e
author, primary.
700
1
|a
Ghosh, Phalguni,
|e
advisor.
700
1
|a
Lavey, Brian,
|e
advisor.
700
|a
Middlesex College, Department of Natural Sciences.
|4
spn
830
0
|a
Middlesex County College.
830
0
|a
Student Symposium.
830
0
|a
Student Works.
852
|a
MCC
|c
Student Symposium
856
40
|u
http://middlesexcc.sobeklibrary.com/AA00002430/00001
|y
Electronic Resource
992
04
|a
https:/digital.middlesexcc.edu/content/AA/00/00/24/30/00001/Thesis-Xiaoqiao Zhang (Kerry Zhang)-12-23-2015thm.jpg
997
|a
Student Symposium
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