Synthesis of a Regenerative Thiol Chemosensing Fluorescent Probe

Material Information

Title:
Synthesis of a Regenerative Thiol Chemosensing Fluorescent Probe
Series Title:
Student Symposium 2013
Creator:
Yu, Daniel ( Author, Primary )
Ghosh, Phalguni ( Advisor )
Middlesex College, Department of Natural Sciences ( Sponsor )
Place of Publication:
Edison, NJ
Publisher:
Middlesex College
Publication Date:

Subjects

Subjects / Keywords:
College students -- poster presentations ( lcsh )
Student Works -- Natural Sciences -- poster presentations ( lcsh )
Chemistry ( lcsh )
Student works -- Natural Sciences -- academic theses ( lcsh )
Middlesex College (Edison, NJ) -- Student works
Middlesex County College (Edison, NJ) ( lcsh )
Temporal Coverage:
Academic Year 2013-2014 ( 2013 - 2014 )
Spatial Coverage:
New Jersey -- Edison

Notes

Abstract:
The purpose of this research project was to replicate the synthesis and test for the effectiveness of a biological chemosensor. The ringed structure of the molecule, 7-chloro-2,3-dihydro-1H-cyclopenta[b]chromene-1-one, had been previously shown to be opened by a thiol and closed by mercury ions.The exact opening and closing of the ring structure is important due to its control of the fluorescent light emission of the molecule. The chemosensor was synthesized and then tested for its viability as a marker for both thiols and mercury. Findings were consistent with the proposed lock mechanism of the probe molecule in that quantitative differences were seen upon the addition of a thiol and a subsequent regeneration of the probe through the addition of mercury ions. All work was conducted at the Middlesex County College labs with the synthesis and results from the testing subjected to various analytical tools such as IR spectroscopy, column chromatography, UV-Vis and Fluorescent spectroscopy.
Preferred Citation:
Yu, D. Synthesis of a Regenerative Thiol Chemosensing Fluorescent Probe; MCC Student Symposium 2013; Middlesex County College: Edison, NJ, 2013. http://middlesexcc.sobeklibrary.com/AA00002437/00001

Record Information

Source Institution:
Middlesex County College Institution
Holding Location:
Middlesex County College Institution
Rights Management:
All applicable rights reserved by the source institution and holding location.

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