New Methodology Attempted for the Synthesis of Chloramphenicol

Material Information

Title:
New Methodology Attempted for the Synthesis of Chloramphenicol
Series Title:
Student Symposium 2018
Creator:
Bagga, Surleen Singh ( Author, Primary )
Ghosh, Phalguni ( Thesis advisor )
Middlesex College, Department of Natural Sciences ( Sponsor )
Lavey, Brian ( Thesis advisor )
Place of Publication:
Edison, NJ
Publisher:
Middlesex College
Publication Date:

Subjects

Subjects / Keywords:
College students -- poster presentations ( lcsh )
Student Works -- Natural Sciences -- poster presentations ( lcsh )
Chemistry ( lcsh )
Student works -- Natural Sciences -- academic theses ( lcsh )
Middlesex College (Edison, NJ) -- Student works
Middlesex County College (Edison, NJ) ( lcsh )
Temporal Coverage:
Academic Year 2018-2019 ( 2018 - 2019 )
Spatial Coverage:
New Jersey -- Edison

Notes

Abstract:
A new synthetic method for preparation of the antibiotic drug, Chloramphenicol, was proposed. The earlier methods of producing the drug involves utilization of hazardous chemicals. The motive was to find a synthesis method was to utilize as much as non-hazardous materials to prepare the drug. The goal was to optimize the conditions for the adoptions of the methodology in industrial scale. The hypothesis involved using enantioselective catalysts- Diphenyl Prolinol for Michael addition of p-Nitrobenzaldehyde and the amino group. The hypothesis suggests a yield of over 90% of the desired isomer. The Aminodiacetylaldehyde dimethyl acetal was first reacted with Dichloroactyl chloride. The product was then deprotected and further reacted with p-Nitrobenzaldehyde in the presence of the catalyst. Further the desired isomer was reduced with Sodium Borohydride. The expected product obtained would be cis isomer of the required molecule. Further, the molecule would be tested for its antibiotic properties.

Record Information

Source Institution:
Middlesex County College Institution
Holding Location:
Middlesex County College Institution
Rights Management:
All applicable rights reserved by the source institution and holding location.

MCC Membership

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