Bioinformatics Study of the Human Gut Microbiome and Relationship with Disease

Material Information

Title:
Bioinformatics Study of the Human Gut Microbiome and Relationship with Disease
Series Title:
Student Symposium 2021
Creator:
McKinney, Jayme ( Author, Primary )
Ghosh, Phalguni ( Thesis advisor )
Place of Publication:
Edison, NJ
Publisher:
Middlesex College
Publication Date:

Notes

Abstract:
The gut microbiome has many roles within the human body and that are known and speculated. One role is regulating homeostasis within the gut, and another is regulating the inflammatory response within the host human. The gut microbiome is the metabolic pathway for many different substrates and metabolites. Using data from gutMGene that focused on the gut microbiome-chemical interactions that occur in the human body a network was mapped out with Cytoscape to display the most prominent substrates, bacteria, and metabolites within the human gut. Then using research acquired from different articles and gutMDisorder I then accumulated data that showed the relationship between bacteria dysbiosis and disease, I found the diseases that had the most relationships with the gut microbiota from mapping the interactions in Cytoscape. This shows the bacteria that are affected by diseases and whether they have an increasing interaction or a decreasing interaction. This shows us that there is a relationship between the gut microbiome and disease and allows us to see the bacteria that increased and decreased and seeing its connection to chemicals I can see whether the gut microbiome affects inflammation within the gut.

Record Information

Source Institution:
Middlesex County College Institution
Holding Location:
Middlesex County College Institution
Rights Management:
All applicable rights reserved by the source institution and holding location.

MCC Membership

Aggregations:
Middlesex College
Student Symposium
Student Works